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Herbs and Anesthesia
Abdul N. Naushad, M.D.
Resident, Department of Anesthesia
Indiana University School of Medicine
Indianapolis, Indiana
Dedicated to the Indiana University School of Medicine
Department of Anesthesia
Copyright © 2002 by Meo Publishing
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY
BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY
MEANS, ELECTRONIC OR MECHANICAL, INCLUDING
PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE
AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING
FROM THE PUBLISHER.
FOR ANY QUESTIONS OR CONCERNS:
EMAIL: mailto:wajiha_a_naushad@yahoo.com

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PREFACE
The main purpose for writing this small handbook is to have a quick reference guide for
common herbal medications popular with the general public. There have been many
articles published stating the common drug interactions between medicine and herbs.
There are many excellent detailed books in the market on herbs, but I felt there was not a
good, quick, high-yield book on herbs and anesthesia.
At this time, there are no randomized, controlled trials that evaluate the effects of prior
herbal medicine use on the period immediately before, during, and after surgery. My
intention in writing this book is not to persuade anyone against herbal medication, nor is
it my intention to have anyone postpone or cancel any type of surgery. My only focus is
the safety of the patient and to provide them with the best possible care perioperatively.
As I have mentioned in the Background, use of herbal medications is not necessarily a
contraindication for anesthesia. By reading this quick guide, anesthesiologists can be
familiarized with the common herbs, their side effects and interactions, and intraoperative
complications.
Hopefully, readers will benefit from this book and be informed on herbs and anesthesia.
Abdul
N.
Naushad,
M.D.

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HERBS AND ANESTHESIA
Background
Herbs include flowering plants, shrubs, trees, moss, fern, algae, seaweed, or fungus.
Recently, an increased number of people have turned to herbal remedies for a number of
reasons. In 1997, U.S. adults spent more than $3.5 billion on herbal products and billions
more on vitamins, minerals and other dietary supplements. This number has increased to
$14 billion in the year 2000. One in five individuals who takes prescription medications
also takes herbal preparations, high-dose megavitamins, or both. Eisenberg et al.,
estimate that 15 million people who take herbal medicine may be at risk for potential
adverse interactions between their prescription medications and these products. (JAMA.
1998; 280:1569-1575.)
Frighteningly, the production and marketing of the majority of alternative medicines is
unregulated and the companies are not required to demonstrate safety, efficacy or quality
in the same manner as prescription medicines. This is due to the fact that herbal
medications were classified as dietary supplements in the Dietary Supplement Health and
Education Act of 1994.
Currently, there is an inconsistency in safety guidelines for manufacturing, labeling,
promotion of health claims, and potency and purity of compounding. Herbal medications
cannot gain patent rights and, as such, they are not termed “drugs.” The FDA can
“suggest” but cannot require the herbal industry to provide scientific data to its
consumers.
Polypharmacy and physiological alterations that occur during the perioperative period
may cause morbidity and mortality associated with herbal medications. Perioperative
complications that may occur include increased blood pressure, myocardial infarction,
stroke, increased risk of bleeding, prolonged anesthesia, organ transplant rejection, and
interference with many medications. (JAMA. 2001;286:208-216.)
Use of herbal medications is not necessarily a contraindication for anesthesia.
Pending more definitive studies and in the best interest of patient safety, ASA is taking a
leading role in educating the physician as well as the patient about the importance of a
thorough history of a patient’s medication use. Patients should tell their physicians and
physicians should ask about all herbal, dietary or other over-the-counter preparations as
well as prescription medicine that the patient is taking.

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CAYENNE (CAPSICUM ANNUUM)
COMMON USES
Help in digestion of food, GI stimulant, for colic, diarrhea, cramps, toothache,
insufficient peripheral circulation, reducing blood cholesterol and clotting
tendencies, and for preventing arteriosclerosis and heart disease.
MECHANISM OF ACTION
Capsicum contains capsaicinoid constituents, which stimulate digestion and help to aid in
digestion.
ADVERSE REACTIONS
GI irritation, sweating, and flushing of the head and neck, lacrimation, and rhinorrhea.
Excessive amounts of capsicum can lead to gastroenteritis, and hepatic or renal damage.
Capsicum may cause hypocoagubility. Avoid mixing with ACE inhibitors and
theophylline.
POSSIBLE INTERACTION WITH DRUGS
ANTI-HYPERTENSIVE DRUGS: Might interfere by increasing catecholamine
secretion.
ANTIPLATELET DRUGS: Might increase the effects and adverse effects of
antiplatelet drugs.
BARBITURATES AND DRUGS WITH SEDATIVE PROPERTIES: Might enhance
sedative effects.
COCAINE: Might increase cocaine effects.
MAOI’S: Might interfere with the activity of MAOI’s by increasing catecholamine
secretion
DOSAGE
30-120 mg three times daily

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PERIOPERATIVE CONCERNS
May increase bleeding.
PREOPERATIVE DISCONTINUATION
No data
ECHINACEA
COMMON USES
Used to boosts the immune system and helps fight colds and flu; aids wound healing.
MECHANISMS OF ACTION
They inhibit tissue and bacterial hyaluronidase, have anti-inflammatory activity, and
stimulate the anterior pituitary-adrenal cortex.
ADVERSE REACTIONS
May cause hepatoxicity especially when used with other hepatotoxic drugs, i.e., anabolic
steroids or methotrexate. Avoid mixing with anabolic steroids, amiodarone, methotrexate,
ketoconazole, and cyclosporin.
POSSIBLE INTERACTION WITH DRUGS OR DISEASES
IMMUNOSUPPRESSIVE DRUGS: May interfere with their therapy because of its
immunostimulating activity.
IMMUNE DISORDERS: Contraindicated in individuals with AIDS, HIV infection, or
other autoimmune diseases.
DIABETES: Might worsen metabolic control

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DOSAGE
6-9 ml daily
PERIOPERATIVE CONCERNS
Allergic reactions; decreased effectiveness of immunosuppressants; potential for
immunosuppresion with long-term use.
PREOPERATIVE DISCONTINUATION
No Data
EPHEDRA
COMMON USES
Used in many over-the-counter diet aids as an appetite suppressant; also for asthma or
bronchitis.
MECHANISM OF ACTION
The principle alkaloid constituents are ephedrine and pseudo-ephedrine, which can
directly and indirectly stimulate the sympathetic nervous system, increasing systolic and
diastolic blood pressure, increase heart rate, causing peripheral vasoconstriction,
bronchodilation, and CNS stimulation.
ADVERSE REACTION
Dizziness, motor restlessness, anxiety, irritability, insomnia, headache, anorexia, nausea,
vomiting, flushing, tingling, difficulty urinating, tachycardia, heart palpitations,
hyperthermia, drastic increase in blood pressure, heart failure, and death. Avoid
mixing with caffeine, decongestants, stimulants, heart drugs, and antidepressants.
POSSIBLE INTERACTION WITH DRUGS OR DISEASES
CAFFEINE: Increased risk of stimulatory adverse effects of ephedra.

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DIGOXIN: Might cause cardiac arrhythmias.
ERGOTAMINE AND OXYTOCIN: Might cause hypertension.
MAOI’S: Contraindicated; concomitant use of ephedra with MAOI’s might increase risk
of hypertension.
THEOPHYLLINE: Might increase the risk of stimulatory adverse effects.
ANGINA AND HEART DISEASE: Contraindicated due to its cardiac stimulant effects.
HYPERTENSION: Might exacerbate hypertension
PHEOCHROMOCYTOMA: Contraindicated.
ANOREXIA, BULIMIA, CEREBRAL INSUFFICIENCY, HYPERTHYROID,
AND THYROTOXICOSIS: Contraindicated
DOSAGE
15-30 mg daily up to a maximum of 300 mg per day
PERIOPERATIVE CONCERNS
Risk of myocardial ischemia and stroke from tachycardia and hypertension; ventricular
arrhythmias with halothane; long-term use depletes endogenous catecholamines and may
cause intraoperative hemodynamic instability; life-threatening interaction with
monoamine oxidase inhibitors.
PREOPERATIVE DISCONTINUATION
At least 24 hours before surgery
FEVERFEW

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COMMON USES
Used to prevent migraine headaches and for arthritis, rheumatic disease and allergies.
MECHANISM OF ACTION
Feverfew might work in migraine by preventing prostaglandin production.
ADVERSE REACTION
Mouth ulceration; tongue irritation and inflammation, abdominal pain, indigestion,
diarrhea, nausea, and vomiting.
POSSIBLE INTERACTIONS WITH DRUGS
ANTICOAGULANT, ANTIPLATELET DRUGS
:
Feverfew can increase the risk of
bleeding by inhibiting platelet aggregation.
DOSAGES
2.5 leaves daily with or after food. The freeze-dried leaf is taken at 50-125 mg per day.
PERIOPERATIVE CONCERN
Can inhibit platelet activity and increase bleeding especially in patients already taking
certain anticlotting medications. Avoid mixing with aspirin, ticlid, plavix, persantine, and
warfarin.
PREOPERATIVE DISCONTINUATION
No data available
GARLIC
COMMON USES

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Garlic is used for reducing high blood pressure, prevention of coronary heart disease
by improving lipid profile, preventing age-related vascular changes and
atherosclerosis.
MECHANISM OF ACTION
Garlic is most commonly used for its antihyperlipidemic, antihypertensive, and antifungal
effects. However, it is also reported to have antibacterial, antihelmintic, antiviral,
antispasmodic, diaphoretic, expectorant, immunostimulant, and antithrombotic effects.
Garlic has been found to have antithrombotic properties and can increase fibrinolytic
activity, decrease platelet aggregation, and increase prothrombin time.
ADVERSE REACTIONS
Breath odor, mouth and gastrointestinal burning or irritation, heartburn, flatulence,
nausea, vomiting, and diarrhea.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTICOAGULANT/ANTIPLATELET AGENTS: Garlic can enhance the effects of
warfarin (coumadin) as measured by the INR, Garlic might also enhance the effects and
adverse effects of aspirin, plavix, ticlid, lovenox, persantine, and others.
BLEEDING DISORDER
:
Garlic might increase the risk of bleeding; contraindicated.
DOSAGES
600-900 mg daily
PERIOPERATIVE CONCERNS
Potential to increase risk of bleeding, especially when combined with other medications
that inhibit platelet aggregation.
PREOPERATIVE DISCONTINUATION

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At least 7 days before surgery.
GINGER
COMMON USES
Ginger is used for reducing nausea, vomiting, and vertigo.
MECHANISM OF ACTION
Ginger inhibits platelets and prostaglandins, and improves appetite and digestion. It also
has hypoglycemic, hypotensive or hypertensive, and positive cardiac inotropic activities.
Constituents called gingerols demonstrate antipyretic, analgesic, antitussive, cardiotonic,
and sedative properties.
ADVERSE REACTIONS
Ginger can cause dermatitis in sensitive individuals. Large overdoses can cause CNS
depression and cardiac arrhythmias.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTICOAGULANT/ANTIPLATELET DRUGS
:
In excessive amounts might increase
risk of bleeding.
BARBITURATES
:
Ginger might enhance barbiturate effects.
BLOOD PRESSURE THERAPY
:
Due to hypertensive or hypotensive effects, ginger
might interfere with blood pressure drug therapy.
CARDIAC DRUGS
:
Ginger might interfere with cardiac drug therapy due to inotropic
effects.
BLEEDING CONDITIONS:
Excessive doses can interfere with increase risk

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of bleeding especially in patients already taking certain anticlotting medications.
Avoid mixing with aspirin, plavix, ticlid, persantine, or warfarin.
DOSAGES
0.25-1 g dried root three times daily or one cup tea three times daily.
PERIOPERATIVE CONCERNS
Potent inhibitor of thromboxane synthetase; may increase bleeding time and may
increase risk of intraoperative hemodynamic instability.
PREOPERATIVE DISCONTINUATION
At least 7 days before surgery.
GINKGO
COMMON USES
Ginkgo is used for dementia, for improving blood circulation and oxygenation and
for improving memory and mental alertness.
MECHANISM OF ACTION
Ginkgo is primarily used for cognitive disorders and it seems to affect cognitive
deficiency in two ways: it stimulates populations of nerve cells that are still functional,
and it protects nerve cells from pathologic influences. It also inhibits platelet-activating
factor (PAF).
ADVERSE REACTIONS

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Bleeding, seizures, headache, dizziness, palpitations, restlessness, nausea, vomiting,
diarrhea, lack of muscle tone, weakness, allergic skin reactions, and bleeding.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTICOAGULANT, ANTIPLATELET DRUGS
:
Ginkgo can increase risk of bleeding.
Avoid mixing with aspirin, plavix, warfarin, ticlid, and persantine.
MAOIs
:
Ginkgo might potentiate their activity.
BLEEDING DISORDER
:
Ginkgo can decrease platelet aggregation by inhibiting
platelet-activating factor (PAF) and may exacerbate bleeding disorders; use with caution
with aspirin, ticlid, plavix, persantine, or warfarin.
DOSAGES
120-240 mg per day.
PERIOPERATIVE CONCERNS
Potential to increase risk of bleeding, especially when combined with other medications
that inhibit platelet aggregation.
PREOPERATIVE DISCONTINUATION
At least 36 hours before surgery.
GINSENG, PANAX
COMMON USES
Most commonly used as an antioxidant, for improving physical stamina, cognitive

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function, concentration, and work efficiency.
MECHANISM OF ACTION
The principle constituents of panax ginseng are ginsenosides, which interfere with
platelet aggregation and coagulation.
ADVERSE REACTIONS
Panax ginseng can cause insomnia, mastalgia, vaginal bleeding, tachycardia, mania,
cerebral arteritis, Stevens-Johnson syndrome, cholestatic hepatitis, amenorrhea,
decreased appetite, edema, hyperpyrexia, pruritus, rose spots, hypotension, palpitation,
headache, vertigo, euphoria, neonatal death, “ginseng abuse syndrome” and bleeding.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTICOAGULANT/ANTIPLATELET AGENTS
:
May decrease effectiveness of
warfarin (decreased INR). Avoid mixing with aspirin, warfarin, ticlid, plavix, or
persantine.
DIGOXIN
:
Concomitant use might have synergistic effects in people with CHF.
ANTIDIABETES DRUGS
:
Concomitant use might enhance blood glucose lowering
effects.
MAOIs
:
Concomitant use with phenelzine is associated with insomnia, headache,
tremors, and hypomania.
BLEEDING CONDITIONS
:
Contraindicated in cases of hemorrhage or thrombosis.
DOSAGES
Cut or powdered root is taken orally 0.6-3 g one to three times per day.
PERIOPERATIVE CONCERNS

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Hypoglycemia; potential to increase risk of bleeding; potential to decrease
anticoagulation effect of warfarin.
PREOPERATIVE DISCONTINUATION
At least 7 days before surgery.
GOLDENSEAL
COMMON USES
Used as a mild laxative and also reduces inflammation.
MECHANISM OF ACTION
The principle constituents are berberine and hydrastine, which has antibacterial and
amoebicidal properties.
ADVERSE REACTIONS
Digestive disorders, constipation, excitatory states, hallucinations, and occasionally
delirium. Overdose may cause paralysis (amount not known).
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTIHYPERTENSIVE DRUGS
:
Might interfere with blood pressure control due to
vasoconstrictive action of constituent hydrastine.
BARBITURATES
:
Might potentiate barbiturate induced sleep time.
HEPARIN
:
Might inhibit anticoagulant effects due to the constituent berberine.

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SEDATIVE DRUGS
:
Concomitant use with drugs with sedative properties might cause
additive effects and side effects.
CARDIOVASCULAR DISEASE
:
Theoretically, low doses can increase coronary blood
flow and stimulate the heart, while large doses can inhibit cardiac function.
BLEEDING DISORDERS
:
Use with caution due to berberine, which can inhibit
anticoagulant effects
DOSAGES
0.5-1 g three times daily
PERIOPERATIVE CONCERNS
May worsen edema and/or hypertension.
PREOPERATIVE DISCONTINUATION
No data.

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KAVA
COMMON USES
Kava is used to treat anxiety disorders, stress, insomnia, restlessness, and for
nervousness. It is used as a muscle relaxant, and sedative.
MECHANISM OF ACTION
Kava has been found to have a variety of CNS effects, including anxiolytic, sedative,
anticonvulsant, local anesthetic, spasmolytic, and analgesic activities; however, the exact
mechanism for these effects is not known.
ADVERSE REACTIONS
Gastrointestinal complaints, headache, dizziness, enlarge pupils and disturbances of
oculomotor equilibrium and accommodation. Kava can cause drowsiness and might
impair motor reflexes.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
CNS DEPRESSANTS
:
Concomitant use of alcohol, barbiturates, benzodiazepines, or
any sedative drugs can increase drug effects, risk of adverse effects and increase sedation.
DEPRESSION
:
Kava is contraindicated in endogenous depression, due to the
theoretical sedative activity. Might increase suicide risk.
DOSAGES
100 mg (70 mg kava-lactones) three times daily
PERIOPERATIVE CONCERNS
Potential to increase sedative effect of anesthetics.
PREOPERATIVE DISCONTINUATION

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At least 24 hours before surgery.
LICORICE
COMMON USES
Used for treating stomach ulcers.
.
MECHANISM OF ACTION
Licorice has antispasmodic, anti-inflammatory, expectorant, laxative, and soothing
properties. The constituents, glycyrrhizin and glycyrrhetinic acid, inhibit 11-beta-
hydroxysteroid dehydrogenase which may contribute to licorice associated
mineralocorticoid side effects including hypertension and hypokalemia.
ADVERSE REACTIONS
The use of licorice can cause amenorrhea. Large amounts can cause hypertension,
lethargy, headache, sodium and water retention, edema, and hypokalemia.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTIHYPERTENSIVE DRUGS
:
Large amounts of licorice can cause sodium and water
retention, and hypertension.
DIGOXIN
:
Might increase the risk of cardiac toxicity due to potassium loss.
MAOIs
:
Might increase their effects.
HEART DISEASE
:
Licorice is contraindicated in congestive heart failure.
LIVER DISEASE
:
Licorice is contraindicated in cholestatic liver disorders and liver
cirrhosis.
DIABETES
:
Contraindicated; licorice can interfere with blood glucose control.

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HYPOKALEMIA, RENAL INSUFFICIENCY, AND HYPERTONIA
:
Contraindicated.
DOSAGES
1-4 g of the powdered root or one cup of the tea three times daily.
PERIOPERATIVE CONCERNS
My cause high blood pressure, swelling or electrolyte imbalance.
PREOPERATIVE DISCONTINUATION
No data.
SAW PALMETTO
COMMON USES
Saw palmetto is used for benign prostatic hyperplasia (BPH) and urinary inflammation.
Saw palmetto is used in combination with seven herbs (PC-SPES) to treat prostate
cancer.
MECHANISM OF ACTION
It is believed that saw palmetto inhibits dihydrotestosterone binding at androgen
receptors and 5-alpha-reductase activity on testosterone, preventing the conversion of
testosterone to DHT. Besides possible hormonal mechanisms, saw palmetto might inhibit
growth factors and exert an anti-inflammatory effects.
ADVERSE REACTIONS

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Headache, or may cause erectile dysfunction, ejaculatory disturbance, or altered libido.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ORAL CONTRACEPTIVES, HORMONE THERAPY
:
Concomitant use can interfere.
DOSAGES
1-2 g daily
PERIOPERATIVE CONCERNS
No data
PREOPERATIVE DISCONTINUATION
No data.
ST. JOHN’S WORT
COMMON USES

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St. john’s WORT is used for mild to moderate depression or anxiety, and sleep disorder.
MECHANISM OF ACTION
Inhibition of neurotransmitter reuptake, monoamine oxidase inhibition is unlikely.
ADVERSE REACTIONS
Vivid dreams, restlessness, agitation, irritability, gastrointestinal discomfort, fatigue, dry
mouth, dizziness, and headache.
POSSIBLE INTERACTIONS WITH DRUGS OR DISEASES
ANTIDEPRESSANTS
:
Concomitant use can lead to increase adverse effects and
increase the risk of serotonergic side effects.
BARBITURATES, BENZODIAZEPINES, OR OTHER SEDATIVE DRUGS: Might
increase risk of sedation.
DIGOXIN
:
Might reduce serum level.
PROTEASE INHIBITORS
:
Might reduce serum concentration.
THEOPHYLLINE
:
Might reduce serum levels and the therapeutic effects.
CYCLOSPORINE
:
May decrease plasma cyclosporine levels.
WARFARIN
:
Concomitant use might decrease the therapeutic effects of warfarin.
OTHER DRUGS:
Based on documented interactions with St. John's Wort and drugs
metabolized by cytochrome P450 and St. John’s Wort’s affects on P-glycoproteine, use
caution when considering concomitant use of St.. John’s Wort and other drugs affected
by these systems. Drugs which might be affected include some calcium channel
blockers (diltiazem, verapamil, nicardipine), chemotherapeutic agents (etoposide,
paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole),
glucocorticoids, cisapride (propulsid), losartan (cozaar), fluoxetine (Prozac),
omeprazole (prilosec), fexofenadine (allegra), possible interaction with MAOIs (not

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proven) and others.
DOSAGES
300 mg three times daily
PERIOPERATIVE CONCERNS
May prolong effects of anesthesia. Induction of cytochrome P450 enzymes, affecting
cyclosporine, warfarin, steroids, protease inhibitors, and possibly benzodiazepines,
calcium channel blockers, and many other drugs; decreased serum digoxin levels.
PREOPERATIVE DISCONTINUATION
At least 5 days before surgery.
VALERIAN
COMMON USES
Mild sedative or sleep-aid; also a muscle relaxant.
MECHANISM OF ACTION
Valerian is reported to have sedative-hypnotic, anxiolytic, antidepressant, anticonvulsant,
and antispasmodic effects.
ADVERSE REACTIONS
Headache, excitability, cardiac disturbances, and insomnia.

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POSSIBLE INTERACTIONS WITH DRUGS
ALCOHOL
:
Valerian can potentiate the sedative effects of alcohol.
BARBITURATES, BENZODIAZEPINES, AND OTHER DRUGS WITH SEDATIVE
PROPERTIES
:
Concomitant use can additive therapeutic and adverse effects.
DOSAGES
One cup of the tea taken one to several times per day. The maximum dose is 15 g of the
root per day.
PERIOPERATIVE CONCERNS
Potential to increase sedative effect of anesthetics; benzodiazepine-like acute
withdrawal; potential to increase anesthetic requirements with long -term use.
PREOPERATIVE DISCONTINUATION
No data.

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Effects of herbal medications and recommendations
for discontinuation of use before surgery
Herb
(other names)
Relevant effects
Perioperative concerns
Recommendations
Echinacea
Boosts immunity
Allergic reactions, impairs immune
suppressive drugs, can cause
immune suppression when taken
long-term, could impair wound
healing.
Discontinue as far in
advance as possible,
especially for transplant
patients or those with liver
dysfunction.
Ephedra (ma
huang)
Increases heart
rate, increases
blood pressure
Risk of heart attack, arrhythmias,
stroke, interaction with other drugs,
kidney stones.
Discontinue at least 24
hours before surgery.
Garlic (ajo)
Prevents clotting
Risk of bleeding, especially when
combined with other drugs that inhibit
clotting.
Discontinue at least 7
days before surgery.
Ginko (duck foot,
maidenhair, silver
apricot)
Prevents clotting
Risk of bleeding, especially when
combined with other drugs that inhibit
clotting.
Discontinue at least 36
hours before surgery.
Ginseng
Lowers blood
glucose, inhibits
clotting,
Lowers blood-sugar levels. Increases
risk of bleeding. Interferes with
warfarin (an anti-clotting drug).
Discontinue at least 7
days before surgery.
Kava (kawa, awa,
intoxicating
pepper)
Sedates,
decreases anxiety
May increase sedative effects of
anesthesia. Risks of addiction,
tolerance and withdrawal unknown.
Discontinue at least 24
hours before surgery.
St. John's wort
(amber,
goatweed,
Hypericum,
klamatheweed)
Inhibits re-uptake
of neuro-
transmitters
(similar to Prozac)
Alters metabolisms of other drugs
such as cyclosporin (for transplant
patients), warfarin, steroids, protease
inhibitors (vs HIV). May interfere with
many other drugs.
Discontinue at least 5
days before surgery.
Valerian
Sedates
Could increase effects of sedatives.
Long-term use could increase the
amount of anesthesia needed.
Withdrawal symptoms resemble
Valium addiction.
If possible, taper dose
weeks before surgery. If
not, continue use until
surgery. Treat withdrawal
symptoms with
benzodiazepines.

Page 24
Herb
JAMA article: potential ASA pamphlet: potential
side effect
risks
side
effect
risks
Echinacea
Immune suppression (could
liver inflammation in combination
interfere with wound healing) with certain drugs
Ephedra
Heartbeat irregularities
blood pressure and/or heart rate
(ma huang)
Feverfew
bleeding
Garlic
bleeding
bleeding
Ginger
bleeding
Ginkgo biloba bleeding
bleeding
Ginseng
bleeding; low blood sugar
blood pressure and/or heart rate;
interaction
with
anticlotting
medications
Goldenseal
high
blood
pressure;
swelling
Kava
increase anesthesia effects
increase antiseizure medication
and/or
anesthesia
effects
Licorice high
blood
pressure;
swelling;
electrolyte
imbalances
Saw palmetto
interact
with other hormone therapies
St. John’s wort increase metabolism of drugs
prolong anesthesia effects
used before and after operations
Valerian
increase anesthesia effects
increase antiseizure medication
effects
or
prolong
anesthesia
effects

Page 25
Recommendations
• Anesthesiologists should ask patients if they are
taking any herbal medications.
• Surgeons should also ask their patients about any
herbal medications or multi-vitamins, which may
contain herbs.
• It is wise to be familiar with all the common
herbs and their drug interactions.
• If a patient is on any herbal remedy on the day of
surgery, let the patient know of any potential side
effects and intraoperative complications. Also
make sure to involve the surgeon in the final
decision.
• If the procedure has an increased potential of
blood loss, or if the patient is susceptible to
increased blood loss, keep alternatives in mind.
With consultation of patient and surgeon, some
elective cases may be cancelled.

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HERB-DRUG INTERACTION
Potential Interactions Between Drugs
and Commonly Used Natural
Medicines
DRUGS NATURAL MEDICINE
Aspirin
Licorice
Naloxone (Narcan)
Yohimbe
Narcotics
St.
john’s
Wort
NSAIDs
Feverfew,
Licorice
Protease
inhibitors
St.
john’s
Wort
Macrolide
Antibiotics
Digitalis
Penicillin
Guar
Gum
Quinine
Digitalis
Anticoagulants/Antiplatelets
Ginsen, Garlic, Ginkgo, Goldensale,
Feverfew.
Heparin
Goldenseal

Page 27
DRUGS NATURAL MEDICINE
Warfarin
Ginseng,
Ginkgo,
St.
john’s
Wort.
Danshen,
Papain,
Belbery,
Devils
Claw, Guarana.
Antihypertensives
Yohimbe.
Ginger, Licorice, Goldenseal,
Beta-Blockers
Coffee,
Yohimbe
Calcium Channel Blockers
St. john’s Wort
Digoxin
D
St. john’s Wort, Guarana, Hawthorn.
igitalis,
Ephedra,
Licorice,
Clonidine
Yohimbe
Thiazide
Diuretics
Ginkgo
K-Depleting
Diuretics
Licorice,
Guarana
Reserpine
St.
john’s
Wort
5-HTI Agonists (“Tritans”)
St. john’s Wort
SSRIs
St.
john’s
Wort
Antidepressant
St.
john’s
Wort
MAOIs G
Caffeine, Cocoa, Yohimbe, Guarana
inseng,
Ginkgo,
Ephedra,
Coffee,
Tricyclics
St.
john’s
Wort,
Yohimbe
CNS
Depressants
Kava, Hawthorn, Melatonine

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DRUGS NATURAL MEDICINE
Alcohol
Kava,
Ginseng,
Valerian
CNS
Stimulants
Ginseng
Levodopa
Kava
Sedatives
Kava,
Ginseng,
Goldenseal,
Valerian
Barbiturates
Kava,
Valerian,
St.
john’s
Wort,
Ginger, Ginseng, Goldenseal
Benzodiazepines
Kava,
Valerian
Oral
Hypoglycemics
Ginseng, Ephedra, Garlic, coffee
Corticosteroids
Licorice
Hormone
Therapy
Ginseng,
Licorice,
Saw
Palmetto
Oral Contraceptives
Saw Palmetto, St. john’s Wort
Oxytocin
Ephedra
Cyclosporine St.
john’s
Wort
Immunosuppressants
Echinacea
Photosensitizing
Drugs
St.
john’s
Wort
Theophylline Ephedra,
Caffeine,
St.
john’s
Wort

Page 29
SOME BRAND NAME
NATURAL PRODUCTS-
WHAT THEY CONTAIN
METABOLIFE 356
Each tablet contains:
Guarana (contains caffeine 40 mg)
Ma huang (contains ephedrine 12 mg)
Siberian Ginseng
Ginger root
Goldenseal
Lecithin
Damiana
Sarsaparilla root
Gotu Kola
Spirulina Algae
Bee Pollen
Nettle Leaf
Royal Jelly
Bovine Complex
Other ingredients: Vitamin E 6 IU, Magnesium Chelate 75 mg, Zinc Chelate 5 mg,
and Chromium Picolinate 75 mg.
PC-SPES

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Each capsule contains:
Licorice (Glycyrrhiza glabra, Glycyrrhiza uralensis)
Da Qing Ye (Isatis indigotica)
San Qi (Panax Pseudoginseng)
Reishi Mushroom (Ganoderma lucidum)
Baikal Skullcap (Scutellaria baicalensis)
Chrysanthemum (Dendranthema morifolium)
Rabdosia Rebescens
Saw Palmetto (Serenoe repens)
PC-SPES has been available commercially since 1996. “PC” stands for prostate cancer
and “SPES” is Latin for hope. It contains licorice and panax-pseudoginseng (both have
estrogenic activity) and saw palmetto (which inhibit 5-alpha reductase i.e antiandrogenic
effect).
Reported side effects of PC-SPES include lowered libido, erectile dysfunction, hot
flashes, breast tenderness/enlargement, reduction in overall body hair, pitting edema,
significant drop in lipoprotein a, and venous thrombosis.
A.S.A.P.
Ingredients: Black Cohosh root, Passionflower herb, Scullcap herb, Valerian root,
Lobelia leaf, Prickly Ash bark.
AD-FX
Ingredients: HT-1001 biologically standardized extract (American Ginseng containing
> 15% ginsenosides) 125 mg, Ginkgo biloba standardized extract 29 mg (containing
>4% terpenelactones).
ADAPTRIN

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Ingredients: Iceland Moss, Red Sandalwood, Hardy Orange, Betriver, Margosa, Spiral
Flag, White Sandalwood, Cloves, Columbine, Wild Lettuce, Marigold, Knotgrass,
Licorice, Valerian, Camphor bark, Gypsum, Cardamon, Jamaican Pepper, Ribwort
(plantain), Heartleaved Sida, Myrobalan, Blackthorn, Golden Cinquefoil, Gingerlily,
Homeopatheic Monkshood.
ALLERGIA
Ingredients: Bitter Orange, Ginger, Panax Ginseng, Blackberry, Kudzu, HerbaSwee
(Cucurbitaceae fruit)
AM PLUS (BRAIN 111 FORMULA)
Ingredients: Ginkgo Biloba, Korean Ginseng, Ginger root, Echinacea augustifolia, Beet
root powder, Peppermint leaves, Licorice root, Aloe Vera, Kava Kava.
AMERICAN GINSENG
Ingredients: American Ginseng root, Licorice root, Ginger rhizome, Cinnamon bark,
Sarsaparilla root, Dong Quai root.
Diet-Metabo-7
Ingredients: Green Tea leaf extract, Guggul Yogaraj Gum Resin, Kola nut extract,
Dandelion extract, Yerba Mate extract, Bupleurum root, Horse Chestnut extract,
Bladderwrack extract, Ginkgo Biloba leaf extract, Ginger root, Black Pepper fruit extract,
Iodine.
GINKOGIN
Ingredients: Ginkgo, Ginger, Garlic
GINKGO-COMBO GINKGO BILOBA COMPLEX IN
VEGETARIAN CAPSULES
Ingredients: Ginkgo Biloba, Capsicum fruit, Gotu Kola root.
MALE ADVANTAGE
Ingredients: Saw Palmetto Berry Fruit Extract, Kava Kava Root, Flaxseed, Pumpkin
seed, Korean Ginseng root, Siberian Ginseng root, Turmeric root extract, Damiana leaf,

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Pygeum Africana Bark wet extract, Gotu Kola whole plant, Bromelain.
MASCULEX
Ingredients: Muira Puama Powdered extract, Liquid Liver Fractions, Wheat Germ oil
concentrate, Mexican Damiana leaves extract, Saw Palmetto Berry extract, Cola Nut,
Panax ginseng extract, Ginkgo Biloba leaves extract.
MASCULPLEX
Ingredients: Muira Puama powdered extract, Liquid Liver Fractions, Wheat Germ oil
concentrate, Mexican Damania leaves, Saw palmetto Berry extract, Cola nut extract,
Panax Ginseng extract, Ginkgo Biloba leaves extract.
MEMORY
Ingredients: Ginkgo Biloba extract, Memorzine, Korean Ginseng.
MEMORY FORMULA
Ingredients: Ginkgo Biloba leaf, Gotu Kola herb, Cayenne pepper, Siberian Ginseng
MEN’S AM MULTI
Ingredients: RoseOx, Citrus Bioflavanoid Complex, Saw Palmetto Berries, Whole Oats,
Panax Ginseng Extract, Gingko Biloba Leaf, Echinacea, and others.
METAB-O-LITE
Ingredients: Ephedra, Siberian Ginseng, Ginger, Damiana, Sarsaparilla, Gotu Kola,
Goldenseal, Nettles.
ONE-A-DAY BEDTIME & REST
Ingredients: Kava Kava, Valerian, Rosemary Leaf
ONE-A-DAY COLD SEASON

Page 33
Ingredients: Echinacea
ONE-A-DAY ENERGY FORMULA
Ingredients: Ginseng
One-A-DAY MEMORY & CONCENTRATION
Ingredients: Ginkgo biloba
ONE-A-DAY PROSTATE HEALTH
Ingredients: Pumpkin Seed oil, Saw Palmetto extract
ONE-A-DAY TENSION & MOOD
Ingredients: Kava Kava, St. John’s Wort

Page 34
REFERENCES
Jellen JM, Gregory P, Batz F, Hitchens, K, et al. Pharmacist’s Letter/Prescriber’s
Letter Natural Medicines Comprehensive Database. 3rd ed. Stockton, CA:
Therapeutic Research Faculty; 2000.
Ang, Lee, MK, Moss, J, & Yuan, C. Herbal Medicines and Perioperative Care.
JAMA, July 11, 2001-Vol. 286 No. 2 pgs 208-215.
American Society of Anesthesiologists (2000). Possible Side Effects and Drug
Interactions. Retrieved February 2, 2002 from the World Wide Web:
http://www.supplementquality.com/news/herbs_and_surgery.html.
American Society of Anesthesiologists. “What You Should Know About Herbal Use
and Anesthesia.” American Society of Anesthesiologist, pamphlet, 1999.
Fetrow, CW, Avila JR. Complementary & Alternatives Medicines. Second Edition
2001 Springhouse Springhouse, Pennsylvania.
Snow, Wyn (2001). Supplements and Surgery--What to Tell Your Doctors.
Retrieved February 7, 2002 from the World Wide Web:
http://www.supplementquality.com/news/herbs_and_surgery.html.
MayoClinic (2001). Herb and drug interactions. Retrieved February 7, 2002 from
the World Wide Web; http://www.mayoclinic.com.